Intermediates

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S.No. Intermediate Name CAS Number Structure API Name
1 Methyl 4-methoxyacetoacetate 41051-15-4 Dolutegravir
2 2,2-Dimethoxyethanamine 22483-09-6 Dolutegravir
3 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3- methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester 13555210-23-5 Dolutegravir
4 2, 4-DifluoroBenzyl Amine 72235-52-0 Dolutegravir
5 3-aminobutan-1-ol 2867-59-6 Dolutegravir
6 (3R)-3-Amino-1-butanol 61477-40-5 Dolutegravir
7 4,4'-bis-chloroacetyl-biphenyl 24860-53-5 Daclatasvir
8 Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate) 1007882-23-6 Daclatasvir
9 4,4'-Bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,1'-biphenyl tetrahydrochloride 1009119-83-8 Daclatasvir
10 Boc-L-Proline 15761-39-4 Daclatasvir
11 Boc-O-Methyl-D-Serine 86123-95-7 Lacosamide
12 2-Piperdin-4-yl-1H-Benzimidazole 38385-95-4 Bilastine
13 2-(2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazo 202189-77-3 Bilastine
14 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride 110963-63-8 Bilastine
15 2-Ethoxyethyl 4-methyl benzenesulfonate 17178-11-9 Bilastine
16 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl) piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole(Bilastine oxazoline intermediate ) 202189-77-3 Bilastine
17 5-chloro-N1-phenylbenzene-1,2-diamine 68406-47-3 Clobazam
18 (S)-Glycidylphthalimide 161596-47-0 Rivaroxaban
19 5-chlorothiophene-2-carboxylic acid 24065-33-6 Rivaroxaban
20 4,6-Dichloro-2-(propylthio)-5-pyrimidinamine 145783-15-9 Ticagrelor
21 4-Chloropyrrolo[2,3-d]pyrimidine 3680-69-1 Tofacitinib
22 6,6-Dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione 5617-70-9 Ketorolac
23 Cyclopropane-1,1-dicarboxylic acid 598-10-7 Ketorolac
24 n-(4-bromphenyl)-3-phenylpropanamide 316146-27-7 Bedaquiline
25 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol 63676-22-2 Raloxifene Hydrochloride
26 6-methanesulfonyloxy-2-(4-methanesulfonyl oxy-phenyl)benzo[b]thiophene 84449-65-0 Raloxifene Hydrochloride
27 [6-[(Methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo [b]thien-3-yl][4-[2-(l-piperidinyl) ethoxy]phenyl]methanone Hydrochloride 84449-85-4 Raloxifene Hydrochloride
28 2-(phenoxymethyl)benzoic acid 724-98-1 Doxepin Hydrochloride
29 dibenzo[b,e]oxepin-11(6H)-one 4504-87-4 Doxepin Hydrochloride
30 4-(4-Chlorophenyl)-1H-benzo[d][1,2]oxazin-1-one 2224-83-1 Chlorthalidone
31 3-(4-Chlorophenyl)isoindolin-1-one 2224-77-3 Chlorthalidone
32 2-(4-Chlorobenzoyl)benzoic acid 85-56-3 Chlorthalidone (Note: Using multiple products)
33 1-(4-Fluoro-phenyl)-5-(2-oxo-4-phenyl-oxazolidin-3-yl) -pentane-1,5-dione Ezetimibe
34 4-(4-Fluorobenzoyl) butyric acid 149437-76-3 Ezetimibe
35 4-[(4-Fluoro-phenylimino)-methyl]-phenol 3382-63-6 Ezetimibe
36 3,4-Dibenzyloxybenzaldehyde 5447-02-9 Droxidopa
37 3,4-dihydroxybenzaldehyde 139-85-5 Droxidopa, Levodopa & Roflumilas
38 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one 147687-17-0 Paliperidone
38 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one 147687-17-0 Paliperidone
39 2-Amino-3-benzyloxypyridine 24016-03-3 Paliperidone
40 (2-isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine dihydrochloride 1185167-55-8 Ritonavir
41 (2-isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine 154212-60-9 Ritonavir
42 (2S)-3-methyl-2-(phenoxycarbonylamino)butanoic acid 126147-70-4 Ritonavir
43 5-(Thiazol-yl-methyl)-4-(Nitro phenyl) Carbonate 144163-97-3 Ritonavir/Lopinavir
44 2,6-Dimethylphenoxyacetic Acid 13335-71-2 Lopinavir
45 2-(2,6-dimethylphenoxy)acetyl chloride 20143-48-0 Lopinavir
46 (S)-Tetrahydro-a-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic Acid 192725-50-1 Lopinavir
47 4-chloro benzophenone 134-85-0 Cetirizine /Levo cetirizine
48 4-Hydrazino benzene sulfonamide HCl 17852-52-7 Celecoxib
49 4-Hydrazino benzoic acid 619-67-0 Deferasirox
50 R-Pentane-1,5-diyl bis(3-(1-(3,4-dimethoxy benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate) dioxalate 96687-52-4 CIS -Atracurium Besylate
51 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 1218-69-5 Deferasirox
52 2-(2-Thienyl)ethyl toluene-p-sulphonate 40412-06-4 Clopidogrel bisulphate
53 (+) 2-(2-Chlorophenyl) glycine methyl ester (Tartrate Salt) 141109-15-1 Clopidogrel bisulphate
54 S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] acetate hydrochloride 1141109-19-5 Clopidogrel bisulphate
55 5-Nitrosalicylic acid 96-97-9 Mesalamine
56 2-Hydroxy-5-methylpyridine/5-Methyl-2(1H)-pyridinone; 1003-68-5 Pirfenidone
57 6-Fluoro-3,4-dihydro-2H-1-Benzopyran-2-Carboxylic acid 99199-60-7 or 129050-20-0 Nebivolol
58 6-fluoro-3,4-dihydro-2-oxiranyl-2H—1-benzopyran 99199-90-3 Nebivolol
59 6-fluoro-4-oxo-3,4-dihydro-2H-chromene-2-carboxylic acid Nebivolol
60 2-phenylpropane-1,3-diol 1570-95-2 Felbamate
61 (1S,5R)-1-phenyl-2-oxo-3-oxa bicyclo[3.1.O ]hexane 96847-53-9 Levomilnacipran
62 2-Oxo-1-phenyl-3-oxabicyclo [3.1.0]-hexane 63106-93-4 Milnacipran
63 3-Chloroanisole /Meta Chloroanisole 2845-89-8 Tramadol HCl
64 6-Chloromethyluracil 18592-13-7 Tipiracil HCl
65 5-Chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione 73742-45-7 Tipiracil HCl
66 2-Amino-1-pyrroline Hydrochloride 7544-75-4 Tipiracil HCl
67 1-(Ethoxycarbonyl)ethyl] triphenylphosphonium bromide 30018-16-7 Sacubitril Sodium
68 1-Isobutyl-4-piperidone 72544-16-2 Rifabutin
69 4-(benzhydryloxy) piperidine Hydrochloride. 58258-01-8 Ebastine
70 1-(Piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one 20662-53-7 Benperidol/Pimozid
71 4-(4-chlorophenyl) piperidin-4-ol 39512-49-7 Loperamide
72 3-Fluoro-4-Morpholin-4-yl-Phenylamine 93246-53-8 Linezolid
73 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 207557-35-5 Vildagliptin
74 L-Prolinamide 7531-52-4 Vildagliptin
75 4-Iodoanisole 696-62-8 Levothyroxine
76 8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine 76272-36-1 Maraviroc
77 8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine fumaric acid salt Maraviroc
78 8-Benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]octane 1189427-66-4 Maraviroc
79 2-(2-Ethoxyphenoxy)ethyl bromide 3259-03-8 Tamsulosin hydrochloride
80 2-Aniline ethanol 122-98-5 Efonidipine hydrochloride
81 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline/ (+/-)-Tetrahydropapaverine 13074-31-2 CIS -Atracurium Besylate/ Atracurium Besylate
82 4-Chloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7 Olmesartan/Telmisartan
83 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5 Duloxetine
84 (±)-trans-4-Cyclohexene-1,2-dicarboxylic acid 15573-40-7 Lurasidone Hydrochloride
85 (1R,2R)-(−)-trans-Cyclohexane-1,2-dicarboxylic acid 46022-05-3 Lurasidone Hydrochloride
86 (1R, 2R)-cyclohexane-1,2-diyldimethanol 65376-05-8 Lurasidone Hydrochloride
87 (1R-trans)-1,2-Cyclohexanedimethanol dimethanesulfonate 186204-35-3 Lurasidone Hydrochloride
88 cis-5-norbornen-endo-2,3-dicarboxylic acid 3813-52-3 Lurasidone Hydrochloride
89 Cis-5-Norbornene-endo-2,3-dicarboxylic anhydride 129-64-6 Lurasidone Hydrochloride
90 Cis-5-Norbornene-exo-2,3-dicarboxylic anhydride 2746-19-2 Lurasidone Hydrochloride
91 (3aR,4R,7S,7aS)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 6319-06-8 Lurasidone Hydrochloride
92 (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione 14805-29-9 Lurasidone Hydrochloride
93 Dimethyl 3-isobutylpentanedioate 145328-03-6 Pregabalin
94 (S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid 181289-25-8 Pregabalin
95 3-Isobutyl glutaric anhydride 185815-59-2 Pregabalin
96 (4-Isobutylpiperidine-2,6-dione 916982-10-0 Pregabalin
97 3-(Carbamoylmethyl)-5-methylhexanoic acid 181289-15-6 Pregabalin
98 (R)-3-(Carbamoylmethyl)-5-methylhexanoic acid 181289-33-8 Pregabalin
99 Chloroacetaldehyde dimethyl acetal 97-97-2 Dolutegravir
100 4-Chloro-n-methyl-2-pyridine-carboxamide 220000-87-3 Sorafenib
101 4-(4-aminophenoxy)-n-methyl-2-pyridine-carboxamide 284462-37-9 Sorafenib
102 4-Chloro-6,7-dimethoxyquinoline 35654-56-9 Cabozantinib
103 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine 190728-25-7 Cabozantinib
104 4-(3-fluorobenzyloxy) benzaldehyde 66742-57-2 Safinamide
105 Diethyl (ethoxy carbonyl) phosphonate 867-13-0 Foscarnet sodium
106 2-(4-chlorophenyl)-2-(2-ethyl-1 3-dioxolan-2-yl)acetonitrile 55474-41-4 Pyrimethamine
107 ((1S,4R)-4-aminocyclopent-2-enyl)methanol Tartarate 229177-52-0 Abacavir sulfate
108 4,6-dichloropyrimidine-2,5-diamine 56830-58-1\70080-76-1 Abacavir sulfate
109 ((1S,4R)-4-aminocyclopent-2-enyl)methanol Tartarate 141271-12-7 Abacavir sulfate
110 ((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl)methanol hydrochloride 172015-79-1 Abacavir sulfate
111 (2R,3S) N-tert-butoxycarbonyl-3-phenylisoserine methyl ester 124605-42-1 Docetaxel side chain
112 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride 20232-39-7 Tetrabenazine
113 4-(2-(N-Methyl-N-(2-pyridyl)amino)ethoxy)benzaldehyde 122321-03-3 Rosiglitazone Maleate
114 5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione 122320-74-5 Rosiglitazone Maleate
115 2-(Methyl-pyridin-2-yl-amino)-ethanol hydrobromide 1185301-15-8 Rosiglitazone Maleate
116 (S)-3-(1-(dimethylamino)ethyl)phenol 139306-10-8 Rivastigmine hydrogen tartrate
117 Ethyl 3-(pyridin-2-ylamino) propanoate 103041-38-9 Dabigatran
118 2-[(4-cyanophenyl) AMINO] ACETIC acid 42288-26-6 Dabigatran
119 3-amino-4-(methylamino)benzoic acid 66315-15-9 Dabigatran
120 3-[(3-Amino-4-Methylamino-Benzoyl)-Pyridin-2-yl-amino]-Propionic Acid Ethyl Ester 212322-56-0 Dabigatran
121 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 211915-84-3 Dabigatran
122 Ethyl-3-(2-(((4-Carbamimidoyl Phenyl) Amino) Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1-H-Benzo[D] Imidazole-5-Carboxamido) Propanoate. 429658-95-7 Dabigatran
123 4-Amino benzonitrile 873-74-5 Dabigatran
124 Methyl 1-[(2′-Cyanobiphenyl-4-Yl) Methyl]-2-Ethoxy-1H-Benzimidazole-7-Carboxylate 139481-44-0 Azilsartan/Candesartan
125 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 91526-18--0 Azilsartan
126 (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide 863127-76-8 Dasatinib
127 (S)-2-Aminobutyramide Hydrochloride(SABAM) 7682-20-4 Levetiracetam
128 3-(Dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanone hydrochloride 37951-53-4 Tapentadol
129 (2R,3R)-1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methyl-3-pentanol 175590-76-8 Tapentadol
130 2-Chloro Tritylchloride 42074-68-0 Clotrimazole
131 Tetra butyl Ammonium Bromide (TBAB) 1643-19-2 Phase transfer catalyst
132 Benzyl triethyl ammonium chloride (TEBA) 56-37-1 Phase transfer catalyst
133 Chloroacetaldehyde 107-20-0 General raw materia
134 4-Diemthyl amino pyridine 1122-58-3 Reagent
135 1-Hydroxybenzotriazole 2592-95-2 Reagent
136 4'-Bromomethyl-2-cyanobiphenyl; (Bromo OTBN) 114772-54-2 All sartan Intermediate
137 L-Valine methyl ester HCl 6306-52-1 Valsartan
138 N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-L-valine methyl ester hydrochloride 482577-59-3 Valsartan
139 4-(2-(Dimethylamino)ethoxy)benzaldehyde 15182-92-0 ITOPRIDE
140 2-amino-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one hydrochloride 35970-31-1 Eliglustat Hemitartrate
141 N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide 1393813-42-7 Macitentan
142 N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-propylsulfamide 1393813-43-8 Macitentan
143 Valeronitrile 110-59-8 BCFI
144 Pentane-1,5-diyl bis(3-(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydro isoquinolin-2(1H)-yl)propanoate) dioxalate 64228-78-0 Atracurium Besylate
145 17-Iodoandrosta-5,16-dien-3beta-ol 32138-69-5 Abiraterone acetate
146 4-(3-fluorobenzyloxy) benzaldehyde 66742-57-2 Safinamide
147 2-(Benzyloxy)-1-broMo-3-nitrobenzene 688363-79-3 Eltrombopag olamine
148 P-(methylthio) phenylacetonitrile 38746-92-8 Etoricoxib
149 2-(4-Methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone(Keto sulphone) 221615-75-4 Etoricoxib
150 (S)-1-Benzyl-3-pyrrolidinol 101385-90-4 Barnidipine hydrochloride
151 Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid 486460-00-8 Sitagliptin
152 Diethyl-dipropylmalonate 6065-63-0 Divaloprex Sodium
153 S)-1-Benzyl-3-pyrrolidinol 122-57-6 Warfarin Sodium
154 4-Hydroxycoumarin 1076-38-6 Warfarin Sodium/Zonisamide
155 1-(2-chloroethyl)piperidine hydrochloride 2008-75-5 Raloxifene
156 4-[2-(1-Piperidinyl)ethoxy]benzoic acid, Hydrochloride Salt 84449-80-9 Raloxifene
157 6-Methoxy-2-(4-methoxyphenyl)benzothiophene 63675-74-1 Raloxifene
158 (6-Methylsulfonyloxy-2-[(4-methylsulfonyloxy)phenyl]benzothiophene) 84449-65-0 Raloxifene
159 4-(5-bromo-2-chlorobenzyl)phenol 864070-18-8 Bexagliflozin
160 4-bromo-1-chloro-2-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methylbenzene 1118567-45-5 Bexagliflozin
161 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene 461432-23-5 Dapagliflozin
162 4-(4-aminophenyl)morpholin-3-one 438056-69-0 Rivaroxaban
163 4-(4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydro chloride 898543-06-1 Rivaroxaban
164 2-(((S)-oxiran-2-yl)methyl)isoindoline-1,3-dione 161596-47-0 Rivaroxaban
165 5-chlorothiophene-2-carboxylic acid 24065-33-6 Rivaroxaban
166 (2S,3R)-3-(3,4-bis(benzyloxy)phenyl)-2-amino-3-hydroxypropanoic acid 106887-48-3 Droxidopa
167 3,4-Dihydroxy benzaldehyde 139-85-5 Droxidopa
168 3,4-bis(Benzyloxy)benzaldehyde 5447-02-9 Droxidopa
169 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride 1402222-66-5 Ticagrelor
170 N-(5-chloro-2-nitrophenyl) benzenamine 25781-92-4 Clobazam
171 Diethyl phenylmalonate 83-13-6 Felbamate
172 3'-Methoxypropiophenone 37951-49-8 Tapentadol
173 3-(Dimethylamino)-1-(3-methoxyphenyl)-2-methyl-1-propanone hydrochloride 37951-53-4 Tapentadol
174 n-(4-bromphenyl)-3-phenylpropanamide 316146-27-7 Bedaquiline
175 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 207557-35-5 Vildagliptin
176 L-Prolinamide 7531-52-4 Vildagliptin
177 3-Aminoadamantan-1-ol 702-82-9 Vildagliptin
178 (R)-3-(Boc-Amino)piperidine 309956-78-3 Linagliptin
179 2-amino-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one hydrochloride 35970-31-1 Eliglustat Hemitartrate
180 2-(Benzyloxy)-1-broMo-3-nitrobenzene 688363-79-3 Eltrombopag olamine
181 4-Formyl-3-methoxybenzonitrile 21962-45-8 Finerenone
182 2-Cyanoethyl 3-oxobutanoate 65193-87-5 Finerenone
183 4-Amino-5-methylpyridin-2-ol 95306-64-2 Finerenone
184 (Z)-2-cyanoethyl 2-(4-cyano-2-methoxybenzylidene)-3-oxobutanoate 1050477-39-8 Finerenone
185 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate 1050477-43-4 Finerenone
186 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate 1050477-44-5 Finerenone
187 3-Dimethylaminophenol 99-07-0 Neostigmine
188 1-(3-Methoxyphenyl)ethanamine 62409-13-6 Rivastigmine
189 4-amino-3-Hydroxy benzoic acid 2374-03-0 Tafamidis
190 2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid 594839-88-0 Tafamidis
191 N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide 1393813-42-7 Macitentan
192 N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-propylsulfamide 1393813-43-8 Macitentan
193 2-(2-Ethoxyphenoxy)ethyl bromide 3259-03-8 Tamsulosin hydrochloride
194 6-Chloromethyluracil 18592-13-7 Tipiracil HCl
195 5-Chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione 73742-45-7 Tipiracil HCl
196 2-Amino-1-pyrroline Hydrochloride 7544-75-4 Tipiracil HCl

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